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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP1
All Species:
19.9
Human Site:
S2
Identified Species:
33.68
UniProt:
P11387
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11387
NP_003277.1
765
90726
S2
_
_
_
_
_
_
M
S
G
D
H
L
H
N
D
Chimpanzee
Pan troglodytes
A9Q1D5
601
69739
Rhesus Macaque
Macaca mulatta
XP_001088021
767
90935
S2
_
_
_
_
_
_
M
S
G
D
H
L
H
N
D
Dog
Lupus familis
XP_534420
1004
115318
S236
L
A
A
P
A
D
M
S
G
D
H
L
H
N
D
Cat
Felis silvestris
Mouse
Mus musculus
Q04750
767
90857
S2
_
_
_
_
_
_
M
S
G
D
H
L
H
N
D
Rat
Rattus norvegicus
Q9WUL0
767
90741
S2
_
_
_
_
_
_
M
S
G
D
H
L
H
N
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509816
781
92543
F17
G
F
M
D
G
Q
Y
F
R
A
I
H
A
D
A
Chicken
Gallus gallus
Frog
Xenopus laevis
P41512
829
98212
S2
_
_
_
_
_
_
M
S
E
D
H
V
Q
N
D
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30189
972
111670
H34
V
T
T
N
G
H
G
H
H
H
H
H
H
S
S
Honey Bee
Apis mellifera
XP_396203
973
114099
K83
S
E
H
R
D
K
E
K
D
R
H
K
H
S
S
Nematode Worm
Caenorhab. elegans
O17966
806
94011
K31
D
E
I
K
K
E
V
K
D
E
P
M
A
S
D
Sea Urchin
Strong. purpuratus
XP_793285
879
100968
K52
S
K
E
G
G
A
V
K
V
I
L
L
S
D
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30181
916
102780
N13
V
S
K
P
V
M
D
N
G
S
G
D
S
D
D
Baker's Yeast
Sacchar. cerevisiae
P04786
769
89977
D5
_
_
_
M
T
I
A
D
A
S
K
V
N
H
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
54.1
99
74.8
N.A.
97
97
N.A.
90.4
N.A.
75
N.A.
N.A.
49.6
53.5
54.8
45.3
Protein Similarity:
100
67.4
99.6
75.8
N.A.
98.6
98.6
N.A.
93.8
N.A.
82.7
N.A.
N.A.
62.3
64.4
69.1
58
P-Site Identity:
100
0
100
60
N.A.
100
100
N.A.
0
N.A.
66.6
N.A.
N.A.
13.3
13.3
6.6
6.6
P-Site Similarity:
100
0
100
60
N.A.
100
100
N.A.
20
N.A.
77.7
N.A.
N.A.
26.6
20
40
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
36.6
46.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
53.3
63.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
41.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
0
8
8
8
0
8
8
0
0
15
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
8
8
8
8
8
15
43
0
8
0
22
58
% D
% Glu:
0
15
8
0
0
8
8
0
8
8
0
0
0
0
8
% E
% Phe:
0
8
0
0
0
0
0
8
0
0
0
0
0
0
0
% F
% Gly:
8
0
0
8
22
0
8
0
43
0
8
0
0
0
8
% G
% His:
0
0
8
0
0
8
0
8
8
8
58
15
50
8
0
% H
% Ile:
0
0
8
0
0
8
0
0
0
8
8
0
0
0
0
% I
% Lys:
0
8
8
8
8
8
0
22
0
0
8
8
0
0
0
% K
% Leu:
8
0
0
0
0
0
0
0
0
0
8
43
0
0
0
% L
% Met:
0
0
8
8
0
8
43
0
0
0
0
8
0
0
0
% M
% Asn:
0
0
0
8
0
0
0
8
0
0
0
0
8
43
0
% N
% Pro:
0
0
0
15
0
0
0
0
0
0
8
0
0
0
0
% P
% Gln:
0
0
0
0
0
8
0
0
0
0
0
0
8
0
0
% Q
% Arg:
0
0
0
8
0
0
0
0
8
8
0
0
0
0
0
% R
% Ser:
15
8
0
0
0
0
0
43
0
15
0
0
15
22
15
% S
% Thr:
0
8
8
0
8
0
0
0
0
0
0
0
0
0
0
% T
% Val:
15
0
0
0
8
0
15
0
8
0
0
15
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% Y
% Spaces:
43
43
43
36
36
36
0
0
0
0
0
0
0
0
0
% _